Česky

Posted: 5. 12. 2019

PhD position in Molecular Parasitology

Institute of Parasitology

Molecular Parasitology

Laboratory of Functional Biology of Protists

Employment contract

Researcher

Fixed-term

Full-time

Job description:

We are seeking a highly motivated individual to join our team working on the unique traits of mitochondrial ribosomes and translation of Trypanosoma brucei, the causative agent of the sleeping sickness. Ribosomes, highly conserved machines fundamental for all life forms, were recently shown to undergo unexpected diversification in endosymbiotic organelles with vestigial genomes. The most divergent ribosomes are found in the mitochondria of parasitic protists from the group of Kinetoplastids, including trypanosomes. In this project, we complement the wealth of structural information on mitoribosomes and their precursors obtained by cryoEM with functional approaches to get detailed insight into lineage specific features of translation in mitochondria of trypanosomes. We aim to understand how the divergent mitoribosomes co-evolved with the peculiar context of the mitochondrial gene expression in the parasite.

The successful applicant will work under the supervision of Ondrej Gahura in the Laboratory of Functional Biology of Protist led by Alena Zíková, at the Institute of Parasitology, Biology Centre of the Czech Academy of Science in Ceske Budejovice (Budweiss), Czech Republic. Our institute is located in the joint campus of Czech Academy and Science and University of Science Bohemia, providing an international and multidisciplinary scientific environment. The historic city of Ceske Budejovice (population 100.000), famous for its Budweiser beer, is a pleasant, safe and affordable place for living, and offers a wide range of freetime activities.

We offer:
• Work with organism with unique molecular and cellular processes and medical importance
• Modern techniques of molecular and structural biology and biochemistry
• Well-equipped laboratory with friendly and international team
• Opportunities to present advances of the project on conferences, network of international collaborations
• Scholarship and partial appointment together fully covering living expenses for at least 3 years

Requirements:

Master's degree

Biology, Biochemistry, or related field

Languages:

Intermediate

Other requirements:

We expect:
• MSc degree or equivalent from Biology, Biochemistry, or related field
• Enthusiasm, commitment and team spirit
• Good English communication skills

Benefits:

• 5 weeks of holiday
• Friendly international working environment
• Subsidized lunch
• Benefits from Social Fund
• Support of leisure time activities

Additional information:

Other comments:

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